CSF Potential Biomarkers Aβ42 and Tau: associations of Apo E Genotype

Results Our data of CSF Ab42 and tau levels in conjunction with ε4 allele had shown specificity and sensitivity of 100% and 42.8% respectively for the detection of AD. Ab42 and Apo E ε4 combination had shown specificity 80.8% and sensitivity 72.1 %. The ε4 allele distribution frequency was 40% and 2.5% in AD and NAD respectively, where as ε4/4 genotype and ε3/4 genotype distribution was 10 % and 50 % respectively. Our data has shown that ε4 allele in combination with Ab42 to have better sensitivity and specificity in the diagnosis of AD. AD patients with at least one ε4 allele had significantly lower CSF Ab42 levels than those without ε4 allele (P < 0.001). There was a positive correlation of Ab42 with low MMSE scores. Conclusions Observation from our study suggest that decreased Ab42 and increased tau level in CSF along with Apo E ε4 allele as risk factors for AD. Our study also shows ε4 allele incidence to be a risk factor for AD.